Clinical heterogeneity of familial colorectal cancer and its influence on screening protocols.

Screening for familial colorectal cancer.

Genetic Heterogeneity in Colorectal Cancer and its Clinical Implications.

Despite the recent advances in the development of complementary diagnostic exams and modern targeted therapies, colorectal cancer remains a major cause of morbidity and mortality worldwide. In this context, a lot of research has been conducted in the last years to find new markers of poor prognosis. The existence of a complex tumour architecture formed by multiple subclones genetically heteroge...

The influence of year-end bonuses on colorectal cancer screening.

OBJECTIVE To estimate the effect of physician bonus eligibility on colorectal cancer (CRC) screening, controlling for patient and primary care physician characteristics. STUDY DESIGN Retrospective study using managed care plan claims data from 2000 and 2001. METHODS Data on 50-year-old commercially insured patients in a managed care health plan were linked to enrollment and provider files. ...

Consensus Molecular Subtypes of Colorectal Cancer and their Clinical Implications

The colorectal cancer (CRC) subtyping consortium has unified six independent molecular classification systems, based on gene expression data, into a single consensus system with four distinct groups, known as the consensus molecular subtypes (CMS); clinical implications are discussed in this review based on articles relevant to the CMS of CRC indexed in PubMed as well as the authors’ own ...

Does age influence screening for colorectal cancer?

OBJECTIVE To evaluate whether patients' age influenced colorectal cancer screening by internal medicine resident physicians in an ambulatory care clinic. METHODS A retrospective chart review of 200 patients aged >50 years to assess the performance of rectal examinations, faecal occult blood testing and flexible sigmoidoscopy. RESULTS Physicians performed rectal examinations in 21 patients 1...